In solid tumours the development of hypoxia leads to enhanced tumour survival and decreased efficacy of cancer treatments such as radiotherapy, some forms of chemotherapy and emerging sensitiser-based approaches that depend on oxygen for maximum efficacy.
Addressing tumour hypoxia remains a clinical unmet need.
Coated in a pH sensitive polymer, StimOxyGen is a nanoparticle formulation that dissolves at low pH and transiently generates oxygen in hypoxic tumours, thereby addressing one of the major bottlenecks to successful treatment of solid tumours.
StimOxyGen has the ability to carry additional therapeutic payloads on the polymer coating.
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